The motif E<i>X</i>E<i>XXX</i>L in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity.

Durand, Loreleï; Duval, Stéphanie; Evagelidis, Alexandra; Guillemot, Johann; Dianati, Vahid; Sikorska, Emilia; Schu, Peter; Day, Robert; Seidah, Nabil G

The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity.

Durand, Loreleï; Duval, Stéphanie; Evagelidis, Alexandra; Guillemot, Johann; Dianati, Vahid; Sikorska, Emilia; Schu, Peter; Day, Robert; Seidah, Nabil G.

Afiliación

Durand L; Laboratory of Biochemical Neuroendocrinology, Clinical Research of Montreal, affiliated with Université de Montréal, Montreal, Quebec H2W 1R7, Canada.
Duval S; Laboratory of Biochemical Neuroendocrinology, Clinical Research of Montreal, affiliated with Université de Montréal, Montreal, Quebec H2W 1R7, Canada.
Evagelidis A; Laboratory of Biochemical Neuroendocrinology, Clinical Research of Montreal, affiliated with Université de Montréal, Montreal, Quebec H2W 1R7, Canada.
Guillemot J; CIRI, Centre International de Recherche en Infectiologie, Team Pathogenesis of Legionella, INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, École Normale Supérieure de Lyon, Université Lyon, Villeurbanne, 69100 France.
Dianati V; Institut de Pharmacologie de Sherbrooke, Department of Surgery/Urology Division, and Faculté de Médecine et des Sciences de la Santé, Sherbrooke, Quebec J 1H 5N4, Canada.
Sikorska E; Faculty of Chemistry, University of Gdansk, Gdansk, 80-233 Poland.
Schu P; Department of Cellular Biochemistry, University Medical Center, Göttingen, Humboldtallee 23, 37073 Goettingen, Germany.
Day R; Institut de Pharmacologie de Sherbrooke, Department of Surgery/Urology Division, and Faculté de Médecine et des Sciences de la Santé, Sherbrooke, Quebec J 1H 5N4, Canada.
Seidah NG; Laboratory of Biochemical Neuroendocrinology, Clinical Research of Montreal, affiliated with Université de Montréal, Montreal, Quebec H2W 1R7, Canada. Electronic address: seidahn@ircm.qc.ca.

J Biol Chem ; 295(7): 2068-2083, 2020 02 14.

Article en En | MEDLINE | ID: mdl-31915245

Asunto(s)

Antígenos CD/genética; Citosol/metabolismo; Transporte de Proteínas/genética; Receptores de Transferrina/genética; Subtilisinas/genética; Factor de Transcripción AP-2/genética; Secuencias de Aminoácidos/genética; Secuencia de Aminoácidos/genética; Antígenos CD/química; Membrana Celular/genética; Movimiento Celular/genética; Citosol/química; Endosomas/genética; Células HEK293; Humanos; Receptores de Transferrina/química; Subtilisinas/química; Red trans-Golgi/genética

Palabras clave

adaptor protein 2 (AP-2); cell sorting; convertase; cytosolic tail (CT); proprotein convertase type 7; protease; protein dynamic; shedding; trafficking; transferrin receptor 1(TfR1)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de Transferrina / Subtilisinas / Antígenos CD / Transporte de Proteínas / Citosol / Factor de Transcripción AP-2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Canadá

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