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Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.
Aslan, Katrin; Turco, Verena; Blobner, Jens; Sonner, Jana K; Liuzzi, Anna Rita; Núñez, Nicolás Gonzalo; De Feo, Donatella; Kickingereder, Philipp; Fischer, Manuel; Green, Ed; Sadik, Ahmed; Friedrich, Mirco; Sanghvi, Khwab; Kilian, Michael; Cichon, Frederik; Wolf, Lara; Jähne, Kristine; von Landenberg, Anna; Bunse, Lukas; Sahm, Felix; Schrimpf, Daniel; Meyer, Jochen; Alexander, Allen; Brugnara, Gianluca; Röth, Ralph; Pfleiderer, Kira; Niesler, Beate; von Deimling, Andreas; Opitz, Christiane; Breckwoldt, Michael O; Heiland, Sabine; Bendszus, Martin; Wick, Wolfgang; Becher, Burkhard; Platten, Michael.
Afiliación
  • Aslan K; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Turco V; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Blobner J; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Sonner JK; Immatics Biotechnologies GmbH, Tübingen, Germany.
  • Liuzzi AR; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Núñez NG; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • De Feo D; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kickingereder P; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Fischer M; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Green E; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Sadik A; Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Friedrich M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Sanghvi K; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Kilian M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Cichon F; Department of Neuroradiology, Heidelberg University Medical Center, Heidelberg, Germany.
  • Wolf L; Department of Neuroradiology, Heidelberg University Medical Center, Heidelberg, Germany.
  • Jähne K; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • von Landenberg A; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Bunse L; Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sahm F; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schrimpf D; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Meyer J; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Alexander A; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Brugnara G; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Röth R; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Pfleiderer K; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Niesler B; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • von Deimling A; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Opitz C; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Breckwoldt MO; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Heiland S; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bendszus M; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Wick W; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Becher B; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.
  • Platten M; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nat Commun ; 11(1): 931, 2020 02 18.
Article en En | MEDLINE | ID: mdl-32071302
Asunto(s)
Antineoplásicos Inmunológicos/farmacología; Neoplasias Encefálicas/tratamiento farmacológico; Resistencia a Antineoplásicos/genética; Glioma/tratamiento farmacológico; Microambiente Tumoral/efectos de los fármacos; Animales; Antineoplásicos Inmunológicos/uso terapéutico; Antígeno B7-1/inmunología; Antígeno B7-1/metabolismo; Antígeno B7-H1/inmunología; Antígeno B7-H1/metabolismo; Neoplasias Encefálicas/diagnóstico por imagen; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/inmunología; Linfocitos T CD8-positivos/efectos de los fármacos; Linfocitos T CD8-positivos/inmunología; Linfocitos T CD8-positivos/metabolismo; Antígeno CTLA-4/antagonistas & inhibidores; Antígeno CTLA-4/inmunología; Antígeno CTLA-4/metabolismo; Línea Celular Tumoral/trasplante; Modelos Animales de Enfermedad; Resistencia a Antineoplásicos/inmunología; Femenino; Glioma/diagnóstico por imagen; Glioma/genética; Glioma/inmunología; Humanos; Macrófagos/efectos de los fármacos; Macrófagos/inmunología; Macrófagos/metabolismo; Imagen por Resonancia Magnética; Masculino; Receptor de Muerte Celular Programada 1/antagonistas & inhibidores; Receptor de Muerte Celular Programada 1/inmunología; Receptor de Muerte Celular Programada 1/metabolismo; Transducción de Señal/efectos de los fármacos; Transducción de Señal/genética; Transducción de Señal/inmunología; Linfocitos T Reguladores/efectos de los fármacos; Linfocitos T Reguladores/inmunología; Microambiente Tumoral/genética; Microambiente Tumoral/inmunología
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Resistencia a Antineoplásicos / Microambiente Tumoral / Antineoplásicos Inmunológicos / Glioma Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Resistencia a Antineoplásicos / Microambiente Tumoral / Antineoplásicos Inmunológicos / Glioma Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania