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The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.
Denomme, Nicholas; Lukowski, April L; Hull, Jacob M; Jameson, Margaret B; Bouza, Alexandra A; Narayan, Alison R H; Isom, Lori L.
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  • Denomme N; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Center for Consciousness Science, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Lukowski AL; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Hull JM; Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Jameson MB; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Molecular and Cellular Pharmacology Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 United States.
  • Bouza AA; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Narayan ARH; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Isom LL; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United
Neurosci Lett ; 724: 134853, 2020 04 17.
Article en En | MEDLINE | ID: mdl-32114117
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tetrodotoxina / Canal de Sodio Activado por Voltaje NAV1.1 / Canal de Sodio Activado por Voltaje NAV1.6 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Animals / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tetrodotoxina / Canal de Sodio Activado por Voltaje NAV1.1 / Canal de Sodio Activado por Voltaje NAV1.6 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Animals / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2020 Tipo del documento: Article