Tuning coordination chemistry through the second sphere in designed metallocoiled coils.

Slope, Louise N; Hill, Michael G; Smith, Catherine F; Teare, Paul; de Cogan, Felicity J; Britton, Melanie M; Peacock, Anna F A

Slope, Louise N; Hill, Michael G; Smith, Catherine F; Teare, Paul; de Cogan, Felicity J; Britton, Melanie M; Peacock, Anna F A.

Afiliación

Slope LN; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
Hill MG; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
Smith CF; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
Teare P; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
de Cogan FJ; Institute of Microbiology and Infection, University of Birmingham, B15 2TT, UK.
Britton MM; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
Peacock AFA; School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Chem Commun (Camb) ; 56(26): 3729-3732, 2020 Apr 04.

Article en En | MEDLINE | ID: mdl-32129331

RESUMEN

The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 â 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.

Asunto(s)

Complejos de Coordinación/química; Gadolinio/química; Péptidos/química; Secuencia de Aminoácidos; Sitios de Unión; Unión Proteica

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Complejos de Coordinación / Gadolinio Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article

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