Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products.

Lee, Brian; Borys, Breanna S; Kallos, Michael S; Rodrigues, Carlos A V; Silva, Teresa P; Cabral, Joaquim M S

Lee, Brian; Borys, Breanna S; Kallos, Michael S; Rodrigues, Carlos A V; Silva, Teresa P; Cabral, Joaquim M S.

Afiliación

Lee B; PBS Biotech, Inc., Camarillo, CA 93012, USA.
Borys BS; Department of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
Kallos MS; Department of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
Rodrigues CAV; Ibb-Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal.
Silva TP; Ibb-Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal.
Cabral JMS; Ibb-Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal.

Bioengineering (Basel) ; 7(2)2020 Mar 28.

Article en En | MEDLINE | ID: mdl-32231012

Palabras clave

U-shaped vessel; Vertical-Wheel; allogeneic cell therapy; cell aggregate; computational fluid dynamics; differentiation; expansion; homogeneous hydrodynamic environment; human embryonic stem cell; induced pluripotent stem cell; scalable manufacturing; scale up; shear stress; single-use bioreactor; turbulent energy dissipation rates

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Bioengineering (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Bioengineering (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos