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Sex differences associated with corpus callosum development in human infants: A longitudinal multimodal imaging study.
Schmied, Astrid; Soda, Takahiro; Gerig, Guido; Styner, Martin; Swanson, Meghan R; Elison, Jed T; Shen, Mark D; McKinstry, Robert C; Pruett, John R; Botteron, Kelly N; Estes, Annette M; Dager, Stephen R; Hazlett, Heather C; Schultz, Robert T; Piven, Joseph; Wolff, Jason J.
Afiliación
  • Schmied A; Department of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.
  • Soda T; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Gerig G; Department of Computer Science & Engineering, New York University, New York City, NY, USA.
  • Styner M; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Swanson MR; School of Behavioral & Brain Sciences, University of Texas at Dallas, Richardson, TX, USA.
  • Elison JT; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
  • Shen MD; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • McKinstry RC; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Pruett JR; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Botteron KN; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Estes AM; Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA.
  • Dager SR; Department of Radiology, University of Washington, Seattle, WA, USA.
  • Hazlett HC; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Schultz RT; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
  • Piven J; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Wolff JJ; Department of Educational Psychology, University of Minnesota, Minneapolis, MN, USA. Electronic address: jjwolff@umn.edu.
Neuroimage ; 215: 116821, 2020 07 15.
Article en En | MEDLINE | ID: mdl-32276067
ABSTRACT
The corpus callosum (CC) is the largest connective pathway in the human brain, linking cerebral hemispheres. There is longstanding debate in the scientific literature whether sex differences are evident in this structure, with many studies indicating the structure is larger in females. However, there are few data pertaining to this issue in infancy, during which time the most rapid developmental changes to the CC occur. In this study, we examined longitudinal brain imaging data collected from 104 infants at ages 6, 12, and 24 months. We identified sex differences in brain-size adjusted CC area and thickness characterized by a steeper rate of growth in males versus females from ages 6-24 months. In contrast to studies of older children and adults, CC size was larger for male compared to female infants. Based on diffusion tensor imaging data, we found that CC thickness is significantly associated with underlying microstructural organization. However, we observed no sex differences in the association between microstructure and thickness, suggesting that the role of factors such as axon density and/or myelination in determining CC size is generally equivalent between sexes. Finally, we found that CC length was negatively associated with nonverbal ability among females.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Desarrollo Infantil / Caracteres Sexuales / Cuerpo Calloso / Imagen de Difusión Tensora Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Desarrollo Infantil / Caracteres Sexuales / Cuerpo Calloso / Imagen de Difusión Tensora Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos