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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Sungnak, Waradon; Huang, Ni; Bécavin, Christophe; Berg, Marijn; Queen, Rachel; Litvinukova, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Sampaziotis, Fotios; Worlock, Kaylee B; Yoshida, Masahiro; Barnes, Josephine L.
Afiliación
  • Sungnak W; Wellcome Sanger Institute, Cambridge, UK. ws4@sanger.ac.uk.
  • Huang N; Wellcome Sanger Institute, Cambridge, UK.
  • Bécavin C; Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
  • Berg M; Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Queen R; Groningen Research Institute for Asthma and COPD, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Litvinukova M; Bioinformatics Core Facility, Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
  • Talavera-López C; Wellcome Sanger Institute, Cambridge, UK.
  • Maatz H; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Reichart D; Wellcome Sanger Institute, Cambridge, UK.
  • Sampaziotis F; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Worlock KB; Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Yoshida M; Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Barnes JL; Department of Medicine, Addenbrookes Hospital, Cambridge, UK.
Nat Med ; 26(5): 681-687, 2020 05.
Article en En | MEDLINE | ID: mdl-32327758
ABSTRACT
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido