TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis.

Appleby-Mallinder, C; Schaber, E; Kirby, J; Shaw, P J; Cooper-Knock, J; Heath, P R; Highley, J R

Appleby-Mallinder, C; Schaber, E; Kirby, J; Shaw, P J; Cooper-Knock, J; Heath, P R; Highley, J R.

Afiliación

Appleby-Mallinder C; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Schaber E; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Kirby J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Heath PR; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.
Highley JR; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.

Neuropathol Appl Neurobiol ; 47(1): 61-72, 2021 02.

Article en En | MEDLINE | ID: mdl-32365404

Asunto(s)

Esclerosis Amiotrófica Lateral/metabolismo; Esclerosis Amiotrófica Lateral/patología; Metilación de ADN/fisiología; Enfermedades Neurodegenerativas/patología; Proteinopatías TDP-43/metabolismo; Citosina/metabolismo; Proteínas de Unión al ADN/metabolismo; Epigénesis Genética; Expresión Génica/fisiología; Humanos; Mutación/genética; Enfermedades Neurodegenerativas/metabolismo

Palabras clave

DNA hydroxymethylation; DNA methylation; amyotrophic lateral sclerosis; epigenetics; motor neurone disease

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Enfermedades Neurodegenerativas / Proteinopatías TDP-43 / Esclerosis Amiotrófica Lateral Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Neuropathol Appl Neurobiol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

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