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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Mackman, Richard L; Mish, Michael; Chin, Gregory; Perry, Jason K; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E; Fletcher, Simon P.
Afiliación
  • Mackman RL; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Mish M; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Chin G; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Perry JK; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Appleby T; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Aktoudianakis V; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Metobo S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Pyun P; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Niu C; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Daffis S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Yu H; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Zheng J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Villasenor AG; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Zablocki J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Chamberlain J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Jin H; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Lee G; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Suekawa-Pirrone K; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Santos R; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Delaney WE; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
  • Fletcher SP; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
J Med Chem ; 63(18): 10188-10203, 2020 09 24.
Article en En | MEDLINE | ID: mdl-32407112
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Piridinas / Pirimidinas / Hepatitis B Crónica / Hexanoles / Receptor Toll-Like 8 Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Piridinas / Pirimidinas / Hepatitis B Crónica / Hexanoles / Receptor Toll-Like 8 Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos