Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with Echinococcus granulosus.
Exp Parasitol
; 215: 107917, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32446699
ABSTRACT
Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Th2
/
Echinococcus granulosus
/
Equinococosis
/
Células Supresoras de Origen Mieloide
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Exp Parasitol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón