A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.

Monachino, Enrico; Jergic, Slobodan; Lewis, Jacob S; Xu, Zhi-Qiang; Lo, Allen T Y; O'Shea, Valerie L; Berger, James M; Dixon, Nicholas E; van Oijen, Antoine M

Monachino, Enrico; Jergic, Slobodan; Lewis, Jacob S; Xu, Zhi-Qiang; Lo, Allen T Y; O'Shea, Valerie L; Berger, James M; Dixon, Nicholas E; van Oijen, Antoine M.

Afiliación

Monachino E; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Zernike Institute for Advanced Materials, University of Groningen, Groningen 9747, the Netherlands.
Jergic S; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Lewis JS; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Xu ZQ; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Lo ATY; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
O'Shea VL; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Berger JM; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dixon NE; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. Electronic address: nickd@uow.edu.au.
van Oijen AM; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. Electronic address: vanoijen@uow.edu.au.

Mol Cell ; 79(1): 140-154.e7, 2020 07 02.

Article en En | MEDLINE | ID: mdl-32464091

Asunto(s)

ADN Primasa/metabolismo; Replicación del ADN; ADN Polimerasa Dirigida por ADN/metabolismo; AdnB Helicasas/metabolismo; Proteínas de Escherichia coli/metabolismo; Escherichia coli/enzimología; Holoenzimas/química; ADN Primasa/genética; ADN Bacteriano; ADN Polimerasa Dirigida por ADN/genética; AdnB Helicasas/genética; Escherichia coli/genética; Proteínas de Escherichia coli/genética; Holoenzimas/genética; Holoenzimas/metabolismo; Conformación Molecular; Unión Proteica; Conformación Proteica

Palabras clave

DNA replication; DnaB helicase; DnaG primase; clamp loader-helicase interaction; conformational switch; polymerase turnover

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Primasa / Holoenzimas / Proteínas de Escherichia coli / ADN Polimerasa Dirigida por ADN / Replicación del ADN / Escherichia coli / AdnB Helicasas Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

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