A novel biosafety level 2 compliant tuberculosis infection model using a &#916;leuD&#916;panCD double auxotroph of Mycobacterium tuberculosis H37Rv and Galleria mellonella.

Asai, Masanori; Li, Yanwen; Spiropoulos, John; Cooley, William; Everest, David; Robertson, Brian D; Langford, Paul R; Newton, Sandra M

A novel biosafety level 2 compliant tuberculosis infection model using a ΔleuDΔpanCD double auxotroph of Mycobacterium tuberculosis H37Rv and Galleria mellonella.

Asai, Masanori; Li, Yanwen; Spiropoulos, John; Cooley, William; Everest, David; Robertson, Brian D; Langford, Paul R; Newton, Sandra M.

Afiliación

Asai M; Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London , London, UK.
Li Y; Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London , London, UK.
Spiropoulos J; Department of Pathology, Animal and Plant Health Agency , Addlestone, UK.
Cooley W; Department of Pathology, Animal and Plant Health Agency , Addlestone, UK.
Everest D; Department of Pathology, Animal and Plant Health Agency , Addlestone, UK.
Robertson BD; MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London , London, UK.
Langford PR; Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London , London, UK.
Newton SM; Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London , London, UK.

Virulence ; 11(1): 811-824, 2020 12.

Article en En | MEDLINE | ID: mdl-32530737

Asunto(s)

Contención de Riesgos Biológicos; Modelos Animales de Enfermedad; Mariposas Nocturnas/microbiología; Mycobacterium tuberculosis/genética; Tuberculosis/microbiología; Animales; Antibacterianos/aislamiento & purificación; Evaluación Preclínica de Medicamentos/métodos; Larva/microbiología; Mediciones Luminiscentes; Mycobacterium tuberculosis/metabolismo; Mycobacterium tuberculosis/patogenicidad; Tuberculosis/tratamiento farmacológico

Palabras clave

Galleria mellonella; Mycobacterium tuberculosis complex; antimycobacterial agents; auxotrophic; drug screening; infection model; mycobacteria; tuberculosis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis / Contención de Riesgos Biológicos / Modelos Animales de Enfermedad / Mariposas Nocturnas / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Virulence Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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