Diverse lncRNA mechanisms in brain development and disease.
Curr Opin Genet Dev
; 65: 42-46, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32554106
ABSTRACT
Long noncoding RNAs (lncRNAs) are a diverse and pervasive class of genes. Recent studies in the mammalian brain have uncovered several novel mechanisms. LncRNA loci are often located in proximity to developmental transcriptional factors. The lncRNA product may act like a transcription factor to control distantly located genes, or in other instances, the lncRNA loci contain DNA regulatory elements that act locally on neighboring genes. Circular RNAs are covalently closed single-stranded RNAs that can control neuronal function by acting as microRNA sponges and additional mechanisms. LncRNAs can also engage in target-directed microRNA degradation to shape the pool of microRNAs and translation. Thus, diverse mechanisms allow lncRNAs to act in the nucleus and cytoplasm to control neuronal fate and function.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Encefalopatías
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Regulación de la Expresión Génica
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ARN Largo no Codificante
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos