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Naringenin-Functionalized Multi-Walled Carbon Nanotubes: A Potential Approach for Site-Specific Remote-Controlled Anticancer Delivery for the Treatment of Lung Cancer Cells.
Morais, Renata P; Novais, Gabrielle B; Sangenito, Leandro S; Santos, André L S; Priefer, Ronny; Morsink, Margreet; Mendonça, Marcelo C; Souto, Eliana B; Severino, Patrícia; Cardoso, Juliana C.
Afiliación
  • Morais RP; Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
  • Novais GB; Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
  • Sangenito LS; Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
  • Santos ALS; Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
  • Priefer R; Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
  • Morsink M; Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
  • Mendonça MC; School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA.
  • Souto EB; Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
  • Severino P; Translational Liver Research, Department of Medical Cell BioPhysics, Technical Medical Centre, Faculty of Science and Technology, University of Twente, 7522 NB Enschede, The Netherlands.
  • Cardoso JC; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, 7522 NB Enschede, The Netherlands.
Int J Mol Sci ; 21(12)2020 Jun 26.
Article en En | MEDLINE | ID: mdl-32604979
ABSTRACT
Multi-walled carbon nanotubes functionalized with naringenin have been developed as new drug carriers to improve the performance of lung cancer treatment. The nanocarrier was characterized by Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy, Raman Spectroscopy, and Differential Scanning Calorimetry (DSC). Drug release rates were determined in vitro by the dialysis method. The cytotoxic profile was evaluated using the MTT assay, against a human skin cell line (hFB) as a model for normal cells, and against an adenocarcinomic human alveolar basal epithelial (A569) cell line as a lung cancer in vitro model. The results demonstrated that the functionalization of carbon nanotubes with naringenin occurred by non-covalent interactions. The release profiles demonstrated a pH-responsive behavior, showing a prolonged release in the tumor pH environment. The naringenin-functionalized carbon nanotubes showed lower cytotoxicity on non-malignant cells (hFB) than free naringenin, with an improved anticancer effect on malignant lung cells (A549) as an in vitro model of lung cancer.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Portadores de Fármacos / Nanotubos de Carbono / Flavanonas / Liberación de Fármacos / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Portadores de Fármacos / Nanotubos de Carbono / Flavanonas / Liberación de Fármacos / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Brasil