A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.

Morton, Derrick J; Jalloh, Binta; Kim, Lily; Kremsky, Isaac; Nair, Rishi J; Nguyen, Khuong B; Rounds, J Christopher; Sterrett, Maria C; Brown, Brianna; Le, Thalia; Karkare, Maya C; McGaughey, Kathryn D; Sheng, Shaoyi; Leung, Sara W; Fasken, Milo B; Moberg, Kenneth H; Corbett, Anita H

Morton, Derrick J; Jalloh, Binta; Kim, Lily; Kremsky, Isaac; Nair, Rishi J; Nguyen, Khuong B; Rounds, J Christopher; Sterrett, Maria C; Brown, Brianna; Le, Thalia; Karkare, Maya C; McGaughey, Kathryn D; Sheng, Shaoyi; Leung, Sara W; Fasken, Milo B; Moberg, Kenneth H; Corbett, Anita H.

Afiliación

Morton DJ; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Jalloh B; Genetics and Molecular Biology Graduate Program, Emory University, NE, Atlanta, Georgia, United States of America.
Kim L; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Kremsky I; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Nair RJ; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Nguyen KB; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Rounds JC; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Sterrett MC; Genetics and Molecular Biology Graduate Program, Emory University, NE, Atlanta, Georgia, United States of America.
Brown B; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Le T; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Karkare MC; Biochemistry, Cell and Developmental Biology Graduate Program, Emory University, NE, Atlanta, Georgia, United States of America.
McGaughey KD; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Sheng S; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Leung SW; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Fasken MB; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Moberg KH; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.
Corbett AH; Department of Biology, RRC 1021, Emory University, NE, Atlanta, Georgia, United States of America.

PLoS Genet ; 16(7): e1008901, 2020 07.

Article en En | MEDLINE | ID: mdl-32645003

Asunto(s)

Enfermedades Cerebelosas/genética; Proteínas del Citoesqueleto/genética; Drosophila melanogaster/genética; Complejo Multienzimático de Ribonucleasas del Exosoma/genética; Proteínas del Tejido Nervioso/genética; Neuronas/metabolismo; Proteínas de Unión al ARN/genética; Sustitución de Aminoácidos/genética; Animales; Sistemas CRISPR-Cas/genética; Enfermedades Cerebelosas/patología; Cerebelo/metabolismo; Cerebelo/patología; Modelos Animales de Enfermedad; Exosomas/genética; Humanos; Mutación/genética; Neuronas/patología; ARN/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cerebelosas / Proteínas de Unión al ARN / Proteínas del Citoesqueleto / Drosophila melanogaster / Complejo Multienzimático de Ribonucleasas del Exosoma / Proteínas del Tejido Nervioso / Neuronas Límite: Animals / Humans Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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