D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2.

Chin, Alfred C; Yovanno, Remy A; Wied, Tyler J; Gershman, Ariel; Lau, Albert Y

Chin, Alfred C; Yovanno, Remy A; Wied, Tyler J; Gershman, Ariel; Lau, Albert Y.

Afiliación

Chin AC; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.
Yovanno RA; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Wied TJ; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gershman A; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lau AY; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: alau@jhmi.edu.

Structure ; 28(10): 1168-1178.e2, 2020 10 06.

Article en En | MEDLINE | ID: mdl-32735769

Asunto(s)

Receptores de Glutamato/química; Receptores de Glutamato/metabolismo; Serina/metabolismo; Sitios de Unión; Ligandos; Simulación de Dinámica Molecular; Mutación; Dominios Proteicos; Receptores de Glutamato/genética; Serina/química; Termodinámica

Palabras clave

GRID2 gene; delta receptor; free energy calculations; glutamate receptors; ligand-gated receptors; molecular dynamics simulations

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Receptores de Glutamato Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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