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Therapeutic efficacy of modified anti-miR21 in metastatic prostate cancer.
Kim, Kyungmin; Kim, Hyun Hee; Lee, Chul-Hee; Kim, Seunghoo; Cheon, Gi Jeong; Kang, Keon Wook; Chung, June-Key; Youn, Hyewon.
Afiliación
  • Kim K; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University
  • Kim HH; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Lee CH; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University Hosp
  • Kim S; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Cheon GJ; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Kang KW; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University
  • Chung JK; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Nuclear Medicine, National Cancer Center, Goyan
  • Youn H; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Imaging Center, Seoul National University Hospital, Se
Biochem Biophys Res Commun ; 529(3): 707-713, 2020 08 27.
Article en En | MEDLINE | ID: mdl-32736696
ABSTRACT
Despite improved therapeutic efficacy of the locked nucleic acid (LNA)- and peptide nucleic acid (PNA)-modified antisense microRNAs (anti-miRs), their wider application in clinical practice is still not thoroughly investigated. This study aimed to investigate the stability and therapeutic efficacy of the modified LNA- and PNA-type anti-miRs in a murine prostate cancer model under various treatment conditions. After verifying the anti-cancer potential of anti-miR21 by targeting tumor suppressor PTEN, the potential of the modified LNA- and PNA-type anti-miR21s was compared in vitro and in vivo. We found that PNA-type anti-miR21 showed better stability and therapeutic efficacy in the xenografted mouse tumor model than the LNA-type anti-miR21. Furthermore, PNA-type anti-miR21 treatment showed reduced tumor metastasis. This study may serve as a ground for exploring diverse choices in therapeutic oligonucleotide modification techniques to improve cancer treatment.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligonucleótidos / Neoplasias de la Próstata / Ácidos Nucleicos de Péptidos / MicroARNs / Antagomirs Límite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 2020 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligonucleótidos / Neoplasias de la Próstata / Ácidos Nucleicos de Péptidos / MicroARNs / Antagomirs Límite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 2020 Tipo del documento: Article