A discrete serotonergic circuit regulates vulnerability to social stress.
Nat Commun
; 11(1): 4218, 2020 08 24.
Article
en En
| MEDLINE
| ID: mdl-32839452
ABSTRACT
Exposure to social stress and dysregulated serotonergic neurotransmission have both been implicated in the etiology of psychiatric disorders. However, the serotonergic circuit involved in stress vulnerability is still unknown. Here, we explored whether a serotonergic input from the dorsal raphe (DR) to ventral tegmental area (VTA) influences vulnerability to social stress. We identified a distinct, anatomically and functionally defined serotonergic subpopulation in the DR that projects to the VTA (5-HTDRâVTA neurons). Moreover, we found that susceptibility to social stress decreased the firing activity of 5-HTDRâVTA neurons. Importantly, the bidirectional manipulation of 5-HTDRâVTA neurons could modulate susceptibility to social stress. Our findings reveal that the activity of 5-HTDRâVTA neurons may be an essential factor in determining individual levels of susceptibility to social stress and suggest that targeting specific serotonergic circuits may aid the development of therapies for the treatment of stress-related disorders.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Área Tegmental Ventral
/
Transmisión Sináptica
/
Neuronas Serotoninérgicas
/
Núcleo Dorsal del Rafe
/
Vías Nerviosas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2020
Tipo del documento:
Article