Effect of RNA silencing suppression activity of chrysanthemum virus B p12 protein on small RNA species.
Arch Virol
; 165(12): 2953-2959, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-33040310
ABSTRACT
Chrysanthemum virus B encodes a multifunctional p12 protein that acts as a transcriptional activator in the nucleus and as a suppressor of RNA silencing in the cytoplasm. Here, we investigated the impact of p12 on accumulation of major classes of small RNAs (sRNAs). The results show dramatic changes in the sRNA profiles characterised by an overall reduction in sRNA accumulation, changes in the pattern of size distribution of canonical siRNAs and in the ratio between sense and antisense strands, lower abundance of siRNAs with a U residue at the 5'-terminus, and changes in the expression of certain miRNAs, most of which were downregulated.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carlavirus
/
ARN de Planta
/
MicroARNs
/
ARN Interferente Pequeño
/
Interferencia de ARN
Idioma:
En
Revista:
Arch Virol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Suecia