Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer.
Medicine (Baltimore)
; 99(43): e22890, 2020 Oct 23.
Article
en En
| MEDLINE
| ID: mdl-33120836
ABSTRACT
Breast cancer is the most common malignancy affecting women worldwide. The insulin-like growth factor 1 (IGF-1) gene encodes a protein responsible for a wide variety of physiological processes, including differentiation and cell proliferation. Despite several studies on tumor tissues, no study has evaluated IGF-1 expression in the peripheral blood of women with recurrent breast cancer.In this cross-sectional study, IGF-1 expression in the peripheral blood of 146 women with breast cancer treated approximately 5 years ago was quantified by quantitative reverse transcription polymerase chain. The women were divided into 2 groups non-recurrence (nâ=â85) and recurrence (nâ=â61). Statistical analysis of the data was performed using ANOVA, Mann-Whitney, and Chi-squared tests (Pâ<â.05).The results showed no significant difference in IGF-1 expression between the non-recurrence and recurrence groups (Pâ=â.988). In the subgroups of patients with lymph node involvement, no statistically significant difference was observed in IGF-1 expression between women with recurrence and those non-recurrence (Pâ=â.113). In patients without lymph node metastases, IGF-1 messenger ribonucleic acid (mRNA) expression levels were significantly higher in the non-recurrence group than in the recurrence group (Pâ=â.019). Furthermore, using the median IGF-1 mRNA expression as the cutoff point, it was obtained a statistically significant difference in tumor histological grade among women with recurrent breast cancer (Pâ=â.042).These data showed significantly higher IGF-1 expression in women without lymph node metastases in the non-recurrence group compared with the recurrence group. In addition, a significant difference was observed in median IGF-1 mRNA expression in relation to tumor histological grade in women with recurrent breast cancer.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Factor I del Crecimiento Similar a la Insulina
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2020
Tipo del documento:
Article