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BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes.
Wasiak, Sylwia; Dzobo, Kim E; Rakai, Brooke D; Kaiser, Yannick; Versloot, Miranda; Bahjat, Mahnoush; Stotz, Stephanie C; Fu, Li; Sweeney, Michael; Johansson, Jan O; Wong, Norman C W; Stroes, Erik S G; Kroon, Jeffrey; Kulikowski, Ewelina.
Afiliación
  • Wasiak S; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Dzobo KE; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Rakai BD; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Kaiser Y; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Versloot M; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Bahjat M; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Stotz SC; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Fu L; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Sweeney M; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Johansson JO; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Wong NCW; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada.
  • Stroes ESG; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Kroon J; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Kulikowski E; Resverlogix Corp, 300-4820 Richard Road SW, Calgary, AB, T3E 6L1, Canada. Ewelina@resverlogix.com.
Clin Epigenetics ; 12(1): 166, 2020 11 11.
Article en En | MEDLINE | ID: mdl-33172487
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Monocitos / Enfermedades Cardiovasculares / Proteínas / Diabetes Mellitus Tipo 2 / Quinazolinonas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2020 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Monocitos / Enfermedades Cardiovasculares / Proteínas / Diabetes Mellitus Tipo 2 / Quinazolinonas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2020 Tipo del documento: Article País de afiliación: Canadá