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A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles.
Claesen, Jan; Spagnolo, Jennifer B; Ramos, Stephany Flores; Kurita, Kenji L; Byrd, Allyson L; Aksenov, Alexander A; Melnik, Alexey V; Wong, Weng R; Wang, Shuo; Hernandez, Ryan D; Donia, Mohamed S; Dorrestein, Pieter C; Kong, Heidi H; Segre, Julia A; Linington, Roger G; Fischbach, Michael A; Lemon, Katherine P.
Afiliación
  • Claesen J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Spagnolo JB; Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.
  • Ramos SF; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
  • Kurita KL; Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.
  • Byrd AL; Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
  • Aksenov AA; Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Melnik AV; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Wong WR; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Wang S; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Hernandez RD; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA.
  • Donia MS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Dorrestein PC; Department of Human Genetics, McGill University and Genome Quebec Innovation Center, Montreal, QC H3A 0C7, Canada.
  • Kong HH; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
  • Segre JA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Linington RG; Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Fischbach MA; Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Lemon KP; Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Sci Transl Med ; 12(570)2020 11 18.
Article en En | MEDLINE | ID: mdl-33208503
The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Folículo Piloso / Microbiota Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Folículo Piloso / Microbiota Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos