Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells.

Bungsy, Manisha; Palmer, Michaela C L; Jeusset, Lucile M; Neudorf, Nicole M; Lichtensztejn, Zelda; Nachtigal, Mark W; McManus, Kirk J

Bungsy, Manisha; Palmer, Michaela C L; Jeusset, Lucile M; Neudorf, Nicole M; Lichtensztejn, Zelda; Nachtigal, Mark W; McManus, Kirk J.

Afiliación

Bungsy M; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Palmer MCL; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Jeusset LM; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Neudorf NM; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Lichtensztejn Z; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Nachtigal MW; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Obstetrics, Gynecology & Reproductive Sciences, Rady
McManus KJ; Research Institute in Oncology & Hematology, Winnipeg, Manitoba, R3E 0V9, Canada; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada. Electronic address: Kirk.McManus@umanitoba.ca.

Cancer Lett ; 500: 194-207, 2021 03 01.

Article en En | MEDLINE | ID: mdl-33290867

Asunto(s)

Proteínas Portadoras/genética; Inestabilidad Cromosómica/genética; Ciclina E/genética; Cistadenocarcinoma Seroso/genética; Proteínas Oncogénicas/genética; Neoplasias Ováricas/genética; Línea Celular Tumoral; Transformación Celular Neoplásica/genética; Cistadenocarcinoma Seroso/patología; Femenino; Amplificación de Genes/genética; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Clasificación del Tumor; Neoplasias Ováricas/patología; Proteínas Ligasas SKP Cullina F-box/genética

Palabras clave

Chromosome instability; High-grade serous ovarian cancer; Quantitative imaging microscopy; RBX1; SCF Complex

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Proteínas Portadoras / Proteínas Oncogénicas / Cistadenocarcinoma Seroso / Ciclina E / Inestabilidad Cromosómica Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cancer Lett Año: 2021 Tipo del documento: Article País de afiliación: Canadá

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