Exosome-mediated delivery of antisense oligonucleotides targeting &#945;-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.

Yang, Jiaolong; Luo, Shilin; Zhang, Jichun; Yu, Ting; Fu, Zhihui; Zheng, Yongfa; Xu, Ximing; Liu, Chaoyang; Fan, Mingxia; Zhang, Zhentao

Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.

Yang, Jiaolong; Luo, Shilin; Zhang, Jichun; Yu, Ting; Fu, Zhihui; Zheng, Yongfa; Xu, Ximing; Liu, Chaoyang; Fan, Mingxia; Zhang, Zhentao.

Afiliación

Yang J; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Luo S; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhang J; Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Yu T; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Fu Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zheng Y; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Xu X; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Liu C; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Research Center for Environment and Health, Zhongnan University of Economics and Law, Wuhan 430073, China.
Fan M; Animal Experiment Center, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: fanmingxia@whu.edu.cn.
Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: zhentaozhang@whu.edu.cn.

Neurobiol Dis ; 148: 105218, 2021 01.

Article en En | MEDLINE | ID: mdl-33296726

Asunto(s)

Neuronas Dopaminérgicas/efectos de los fármacos; Exosomas; Locomoción/efectos de los fármacos; Oligonucleótidos Antisentido/farmacología; Enfermedad de Parkinson/metabolismo; alfa-Sinucleína/efectos de los fármacos; Animales; Modelos Animales de Enfermedad; Neuronas Dopaminérgicas/metabolismo; Neuronas Dopaminérgicas/patología; Portadores de Fármacos; Humanos; Inyecciones Intraventriculares; Ratones; Ratones Transgénicos; Enfermedad de Parkinson/genética; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo

Palabras clave

Antisense oligonucleotides; Exosomes; Parkinson's disease; Phosphorylated α-synuclein; α-synuclein

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Oligonucleótidos Antisentido / Alfa-Sinucleína / Exosomas / Neuronas Dopaminérgicas / Locomoción Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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