Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.
Development
; 148(2)2021 01 21.
Article
en En
| MEDLINE
| ID: mdl-33323370
ABSTRACT
The control of size and shape is an important part of regulatory process during organogenesis. Tooth formation is a highly complex process that fine-tunes the size and shape of the tooth, which are crucial for its physiological functions. Each tooth consists of a crown and one or more roots. Despite comprehensive knowledge of the mechanism that regulates early tooth crown development, we have limited understanding of the mechanism regulating root patterning and size during development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation. Importantly, activation of Cdc42 can restore cell proliferation and partially rescue the root development size defects in Ror2 mutant mice. Collectively, our findings provide novel insights into the function of Ror2-mediated non-canonical Wnt signaling in regulating tooth morphogenesis, and suggest potential avenues for dental tissue engineering.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Raíz del Diente
/
Proteína de Unión al GTP cdc42
/
Receptores Huérfanos Similares al Receptor Tirosina Quinasa
/
Vía de Señalización Wnt
Límite:
Animals
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos