One-Pot Synthesis of 3-Substituted 4H-Quinolizin-4-ones via Alkyne Substrate Control Strategy.
J Org Chem
; 86(4): 3648-3655, 2021 02 19.
Article
en En
| MEDLINE
| ID: mdl-33372518
ABSTRACT
Three-substituted 4H-quinolizin-4-ones were obtained via a facile method with good selectivity and high efficiency. On the basis of alkyne substrate control, the mild and cost-efficient reaction has a broad substrate scope (20 examples, up to 93% yield) and is also easy to scale up. Active sites on the products allow for further modifications. The alkyne substrate control strategy could be further extended to achieve more complex three-substituted 4H-quinolizin-4-one skeletons.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alquinos
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article