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Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial.
Sperling, Reisa; Henley, David; Aisen, Paul S; Raman, Rema; Donohue, Michael C; Ernstrom, Karin; Rafii, Michael S; Streffer, Johannes; Shi, Yingqi; Karcher, Keith; Raghavan, Nandini; Tymofyeyev, Yevgen; Bogert, Jennifer; Brashear, H Robert; Novak, Gerald; Thipphawong, John; Saad, Ziad S; Kolb, Hartmuth; Rofael, Hany; Sanga, Panna; Romano, Gary.
Afiliación
  • Sperling R; Brigham and Women's Hospital, Boston, Massachusetts.
  • Henley D; Janssen Research & Development LLC, Titusville, New Jersey.
  • Aisen PS; Indiana University School of Medicine, Indianapolis.
  • Raman R; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles.
  • Donohue MC; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles.
  • Ernstrom K; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles.
  • Rafii MS; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles.
  • Streffer J; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles.
  • Shi Y; Janssen Research & Development LLC, Titusville, New Jersey.
  • Karcher K; Translational Medicine Neuroscience, UCB Biopharma SRL, Braine-l'Alleud, Belgium.
  • Raghavan N; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
  • Tymofyeyev Y; Janssen Research & Development LLC, Titusville, New Jersey.
  • Bogert J; Janssen Research & Development LLC, Titusville, New Jersey.
  • Brashear HR; Janssen Research & Development LLC, Titusville, New Jersey.
  • Novak G; Janssen Research & Development LLC, Titusville, New Jersey.
  • Thipphawong J; Janssen Research & Development LLC, Titusville, New Jersey.
  • Saad ZS; Janssen Research & Development LLC, Titusville, New Jersey.
  • Kolb H; Department of Neurology, University of Virginia, Charlottesville.
  • Rofael H; Janssen Research & Development LLC, Titusville, New Jersey.
  • Sanga P; Janssen Research & Development LLC, Titusville, New Jersey.
  • Romano G; Janssen Research & Development LLC, Titusville, New Jersey.
JAMA Neurol ; 78(3): 293-301, 2021 03 01.
Article en En | MEDLINE | ID: mdl-33464300
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Tiazinas / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: JAMA Neurol Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Tiazinas / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: JAMA Neurol Año: 2021 Tipo del documento: Article