Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects.
J Neurol Neurosurg Psychiatry
; 92(12): 1325-1334, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-33495299
ABSTRACT
Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antagonistas del Receptor Peptídico Relacionado con el Gen de la Calcitonina
/
Trastornos Migrañosos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia