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Organic cranberry pomace and its ethanolic extractives as feed supplement in broiler: impacts on serum Ig titers, liver and bursal immunity.
Das, Quail; Tang, Joshua; Yin, Xianhua; Ross, Kelly; Warriner, Keith; Marcone, Massimo F; Diarra, Moussa S.
Afiliación
  • Das Q; Department of Food Science, University of Guelph, Guelph, Ontario Canada N1G 2W1; Guelph Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, Ontario, Canada N1G 5C9.
  • Tang J; Guelph Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, Ontario, Canada N1G 5C9.
  • Yin X; Guelph Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, Ontario, Canada N1G 5C9.
  • Ross K; Summerland Research and Development Centre, AAFC, Summerland, British Columbia, Canada V0H 1Z0.
  • Warriner K; Department of Food Science, University of Guelph, Guelph, Ontario Canada N1G 2W1.
  • Marcone MF; Department of Food Science, University of Guelph, Guelph, Ontario Canada N1G 2W1.
  • Diarra MS; Guelph Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, Ontario, Canada N1G 5C9. Electronic address: moussa.diarra@canada.ca.
Poult Sci ; 100(2): 517-526, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33518104
ABSTRACT
With the pressure to reduce antibiotics use in poultry production, cost-effective alternative products need to be developed to enhance the bird's immunity. The present study evaluated the efficacy of cranberry fruit by-products to modulate immunity in broiler chickens. Broiler Cobb 500 chicks were fed a control basal diet, basal diet supplemented with bacitracin (BACI, 55 ppm), cranberry pomace at 1% and 2% (CP2), or cranberry pomace ethanolic extract at 150 and 300 ppm (COH300) for 30 d. Blood sera were analyzed at days 21 and 28 of age for Ig levels by ELISA. The innate and adaptive immune-related gene expression levels in the liver and bursa of Fabricius were investigated at 21 d of age by quantitative polymerase chain reaction arrays. At day 21, the highest IgY level was found in the blood serum of the CP2-fed birds. In the liver, 13 of the 22 differentially expressed genes were downregulated across all treatments compared with the control. Expression of genes belonging to innate immunity such as caspase 1 apoptosis-related cysteine peptidase, chemokine receptor 5, interferon gamma, myeloid differentiation primary response gene 88, and Toll-like receptor 3 were significantly downregulated mainly in BACI- and COH300-fed birds. In the bursa, 5 of 9 genes associated with the innate immunity were differentially expressed. The expression of anti-inflammatory IL-10 gene was upregulated in all treatment groups in bursa compared with the control. The expression of transferrin gene was significantly upregulated in livers of birds fed COH300 and in bursa of birds fed BACI, indicating feeding practices and organ-dependant modulation of this gene in broiler. Overall results of this study showed that cranberry product feed supplementation modulated the innate immune and suppressed proinflammatory cytokines in broilers, providing a platform for future investigations to develop berry products in poultry feeding.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bolsa de Fabricio / Pollos / Suplementos Dietéticos / Vaccinium macrocarpon / Hígado Límite: Animals Idioma: En Revista: Poult Sci Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bolsa de Fabricio / Pollos / Suplementos Dietéticos / Vaccinium macrocarpon / Hígado Límite: Animals Idioma: En Revista: Poult Sci Año: 2021 Tipo del documento: Article