Acrylamide and its metabolite induce neurotoxicity via modulation of protein kinase C and AMP-activated protein kinase pathways.

Triningsih, Dahlia; Yang, Jae-Ho; Sim, Kyeong Hwa; Lee, Chuhee; Lee, Youn Ju

Triningsih, Dahlia; Yang, Jae-Ho; Sim, Kyeong Hwa; Lee, Chuhee; Lee, Youn Ju.

Afiliación

Triningsih D; Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Yang JH; Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Sim KH; Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Lee C; Department of Biochemistry and Molecular Biology, School of Medicine, Yeungnam University, Daegu, Republic of Korea.
Lee YJ; Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea. Electronic address: whrytn4337@cu.ac.kr.

Toxicol In Vitro ; 72: 105105, 2021 Apr.

Article en En | MEDLINE | ID: mdl-33545342

Asunto(s)

Proteínas Quinasas Activadas por AMP/metabolismo; Acrilamida/toxicidad; Compuestos Epoxi/toxicidad; Proteína Quinasa C/metabolismo; Proteínas Quinasas Activadas por AMP/genética; Animales; Autofagia/efectos de los fármacos; Citocromo P-450 CYP2E1/genética; Citocromo P-450 CYP2E1/metabolismo; Quinasas MAP Reguladas por Señal Extracelular/metabolismo; Síndromes de Neurotoxicidad/metabolismo; Células PC12; Proteína Quinasa C/genética; ARN Interferente Pequeño/genética; Ratas

Palabras clave

AMPK; Acrylamide; Autophagy; Glycidamide; Neurotoxicity; PKC

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína Quinasa C / Acrilamida / Compuestos Epoxi / Proteínas Quinasas Activadas por AMP Límite: Animals Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article

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