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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Uprety, Rajendra; Che, Tao; Zaidi, Saheem A; Grinnell, Steven G; Varga, Balázs R; Faouzi, Abdelfattah; Slocum, Samuel T; Allaoa, Abdullah; Varadi, András; Nelson, Melissa; Bernhard, Sarah M; Kulko, Elizaveta; Le Rouzic, Valerie; Eans, Shainnel O; Simons, Chloe A; Hunkele, Amanda; Subrath, Joan; Pan, Ying Xian; Javitch, Jonathan A; McLaughlin, Jay P; Roth, Bryan L; Pasternak, Gavril W; Katritch, Vsevolod; Majumdar, Susruta.
Afiliación
  • Uprety R; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Che T; Department of Pharmacology, University of North Carolina, Chapel Hill, United States.
  • Zaidi SA; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, United States.
  • Grinnell SG; Department of Anesthesiology, Washington University in St. Louis School of Medicine, St. Louis, United States.
  • Varga BR; Department of Quantitative and Computational Biology, Department of Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, United States.
  • Faouzi A; Division of Molecular Therapeutics, New York State Psychiatric Institute and Departments of Psychiatry, Pharmacology, Columbia University Vagelos College of Physicians & Surgeons, New York, United States.
  • Slocum ST; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, United States.
  • Allaoa A; Department of Anesthesiology, Washington University in St. Louis School of Medicine, St. Louis, United States.
  • Varadi A; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, United States.
  • Nelson M; Department of Anesthesiology, Washington University in St. Louis School of Medicine, St. Louis, United States.
  • Bernhard SM; Department of Pharmacology, University of North Carolina, Chapel Hill, United States.
  • Kulko E; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Le Rouzic V; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Eans SO; Division of Molecular Therapeutics, New York State Psychiatric Institute and Departments of Psychiatry, Pharmacology, Columbia University Vagelos College of Physicians & Surgeons, New York, United States.
  • Simons CA; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, United States.
  • Hunkele A; Division of Molecular Therapeutics, New York State Psychiatric Institute and Departments of Psychiatry, Pharmacology, Columbia University Vagelos College of Physicians & Surgeons, New York, United States.
  • Subrath J; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Pan YX; Department of Pharmacodynamics, University of Florida, Gainesville, United States.
  • Javitch JA; Department of Pharmacodynamics, University of Florida, Gainesville, United States.
  • McLaughlin JP; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Roth BL; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Pasternak GW; Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Katritch V; Department of Anesthesiology, Rutgers New Jersey Medical School, New Jersey, Newark, United States.
  • Majumdar S; Division of Molecular Therapeutics, New York State Psychiatric Institute and Departments of Psychiatry, Pharmacology, Columbia University Vagelos College of Physicians & Surgeons, New York, United States.
Elife ; 102021 02 08.
Article en En | MEDLINE | ID: mdl-33555255
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Opioides kappa / Receptores Opioides mu / Morfinanos Límite: Animals Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Opioides kappa / Receptores Opioides mu / Morfinanos Límite: Animals Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos