Influence of the site of injury on the spontaneous healing response in a rat model of total rupture of the anterior cruciate ligament.
Connect Tissue Res
; 63(2): 138-150, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-33588658
ABSTRACT
AIM:
The healing ability of the anterior cruciate ligament (ACL) injury is very poor; however, it has recently been shown to undergo self-healing with conservative treatments. In this study, we evaluated the influence of the site of injury on the healing process after complete transverse tear of ACL using a rat model. MATERIALS ANDMETHODS:
A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups. The ACL was completely transected in the mid-portion in the ACLT-MP and CAM-MP groups, and on the femoral side in the ACLT-FS and CAM-FS groups. Both CAM groups underwent extra-articular braking to control for abnormal tibial translation. The animals were allowed full cage activity until sacrifice postoperatively for histological and biomechanical assessment.RESULTS:
Significant differences were found in the ratios of residual ligament lengths between the CAM-MP and CAM-FS groups, demonstrating the validity of each model. Spontaneous healing of the injured ACL was observed in the CAM-MP and CAM-FS groups but not in the ACLT-MP and ACLT-FS groups. The mechanical strength of the healing ACL did not differ between the CAM-MP and CAM-FS groups 8 weeks after injury; however, the former had better mechanical strength than the latter 12 weeks after the injury.CONCLUSION:
ACL injuries in the mid-portion and on the femoral side may be treated with conservative therapy for spontaneous healing.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Discinesias
/
Lesiones del Ligamento Cruzado Anterior
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Connect Tissue Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón