[Characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis]. / Caractéristiques de l'atteinte cardiaque au cours de la granulomatose éosinophilique avec polyangéite.
Ann Cardiol Angeiol (Paris)
; 71(2): 95-98, 2022 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-33637317
ABSTRACT
AIM OF THE STUDY Our study aimed to identify the characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA). METHODS:
We conducted a retrospective analytic study including EGPA cases diagnosed between 2000 and 2019 in an internal medicine department. Diagnosis was made according to the 1990 American College of Rheumatology criteria and the 2012 Chapel Hill Concensus.RESULTS:
Eleven EGPA cases were included, 64% of patients were female. Median age at diagnosis was 52 years [42-58]. Heart damage revealed EGPA in 55% of cases with a significant predominance of women (p=0.015). The main cardiac manifestations were myocarditis, ischemic cardiomyopathy due to small vessel vasculitis, cardiac tamponade and intracardiac thrombus. Cardiac magnetic resonance imaging (MRI) mainly showed subendocardial hyposignal in early infusion and late enhancement in the same areas, nodular by locations, associated with impaired left ventricle function and micro-infarctions by distal vasculitis. Cardiac damage was associated to ANCA negativity in 83.3% of cases. The median Birmingham Vasculitis Activity Score version3 (BVAS v3) was 16 [10-17]. Under conventional treatment, no relapses had occurred. The median vasculitis damage index (VDI) was 2 [1-2.3] and the mortality rate was zero after a mean follow-up of 43 months.CONCLUSION:
Cardiomyopathy is a frequent revealing mode of EGPA. A late onset asthma and hypereosinophilia should guide the diagnosis. As ANCA research often turns out to be negative, histological evidence is recommended in this context. The contribution of cardiac MRI in the diagnosis of EGPA remains to be defined.Palabras clave
Antibodies antineutrophil cytoplasmic; Anticorps anti-cytoplasme des polynucléaires neutrophiles; Cardiac tamponade; Cardiomyopathie; Cardiomyopathy; Diagnostic imaging; Eosinophilic granulomatosis with polyangiitis; Granulomatose éosinophilique avec polyangéite; Imagerie diagnostique; Myocardite; Myocarditis; Pericarditis; Péricardite; Tamponnade cardiaque; Vascularite; Vasculitis
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Taponamiento Cardíaco
/
Síndrome de Churg-Strauss
/
Granulomatosis con Poliangitis
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
Fr
Revista:
Ann Cardiol Angeiol (Paris)
Año:
2022
Tipo del documento:
Article