Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets <i>In Vitro via</i> Interference With Phosphatidylinositol 3-Kinase.

Tintinger, Gregory R; Theron, Annette J; Steel, Helen C; Cholo, Moloko C; Nel, Jan G; Feldman, Charles; Anderson, Ronald

Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase.

Tintinger, Gregory R; Theron, Annette J; Steel, Helen C; Cholo, Moloko C; Nel, Jan G; Feldman, Charles; Anderson, Ronald.

Afiliación

Tintinger GR; Department of Internal Medicine, Steve Biko Academic Hospital and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Theron AJ; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Cholo MC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Nel JG; Department of Haematology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Feldman C; Tshwane Academic Division, National Health Laboratory Service of South Africa, Pretoria, South Africa.
Anderson R; Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Front Immunol ; 11: 621148, 2020.

Article en En | MEDLINE | ID: mdl-33717055

Asunto(s)

Adenosina Difosfato/farmacología; Diarilquinolinas/farmacología; Infecciones por VIH/sangre; Fosfatidilinositol 3-Quinasas/metabolismo; Activación Plaquetaria; Infecciones Neumocócicas/sangre; Tuberculosis/sangre; Ácido 15-Hidroxi-11 alfa,9 alfa-(epoximetano)prosta-5,13-dienoico/farmacología; Adulto; Antituberculosos/efectos adversos; Antituberculosos/farmacología; Señalización del Calcio; Diarilquinolinas/efectos adversos; Relación Dosis-Respuesta a Droga; Estrenos/farmacología; Femenino; Infecciones por VIH/fisiopatología; Humanos; Síndrome de QT Prolongado/inducido químicamente; Masculino; Persona de Mediana Edad; Selectina-P/biosíntesis; Selectina-P/genética; Inhibidores de las Quinasa Fosfoinosítidos-3/farmacología; Fosforilación/efectos de los fármacos; Activación Plaquetaria/efectos de los fármacos; Agregación Plaquetaria/efectos de los fármacos; Plasma Rico en Plaquetas; Infecciones Neumocócicas/fisiopatología; Procesamiento Proteico-Postraduccional/efectos de los fármacos; Proteínas Proto-Oncogénicas c-akt/metabolismo; Pirrolidinonas/farmacología; Trombina/farmacología; Tuberculosis/fisiopatología; Wortmanina/farmacología; Adulto Joven

Palabras clave

CD62P; adenosine-5'-triphosphate; bedaquiline; calcium fluxes; phosphatidylinositol 3-kinase; platelets; wortmannin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Tuberculosis / Infecciones por VIH / Activación Plaquetaria / Adenosina Difosfato / Fosfatidilinositol 3-Quinasas / Diarilquinolinas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Sudáfrica

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