Four New Gallate Derivatives from Wine-Processed Corni Fructus and Their Anti-Inflammatory Activities.
Molecules
; 26(7)2021 Mar 25.
Article
en En
| MEDLINE
| ID: mdl-33805990
ABSTRACT
Four new gallate derivatives-ornusgallate A, ent-cornusgallate A, cornusgallate B and C (1a, 1b, 2, 3)-were isolated from the wine-processed fruit of Cornus officinalis. Among them, 1a and 1b are new natural compounds with novel skeletons. Their chemical structures were elucidated by comprehensive spectroscopy methods including NMR, IR, HRESIMS, UV, ECD spectra and single-crystal X-ray diffraction analysis. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. As the result, all compounds exhibited anti-inflammatory activities at attested concentrations. Among the tested compounds, compound 2 exhibited the strongest anti- inflammatory activity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cornus
/
Frutas
/
Ácido Gálico
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China