Two Siblings Homozygous for F508del-CFTR Have Varied Disease Phenotypes and Protein Biomarkers.

Zhang, Zhihong; Wang, Jin; Zhang, Yanhui H; Gardner, Tonia E; Fitzpatrick, Elizabeth A; Zhang, Weiqiang

Zhang, Zhihong; Wang, Jin; Zhang, Yanhui H; Gardner, Tonia E; Fitzpatrick, Elizabeth A; Zhang, Weiqiang.

Afiliación

Zhang Z; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Wang J; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Zhang YH; Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Gardner TE; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Fitzpatrick EA; University of Tennessee Cystic Fibrosis Care and Research Center at Le Bonheur Children's Hospital-Methodist University Hospital, Memphis, TN 38103, USA.
Zhang W; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Int J Mol Sci ; 22(5)2021 Mar 05.

Article en En | MEDLINE | ID: mdl-33807880

Asunto(s)

Secuencia de Aminoácidos; Regulador de Conductancia de Transmembrana de Fibrosis Quística/genética; Fibrosis Quística; Homocigoto; Mediadores de Inflamación/metabolismo; Eliminación de Secuencia; Hermanos; Linfocitos T Colaboradores-Inductores/metabolismo; Biomarcadores/metabolismo; Fibrosis Quística/genética; Fibrosis Quística/metabolismo; Femenino; Humanos; Elastasa de Leucocito/metabolismo; Masculino; Esputo/metabolismo

Palabras clave

CFTR; F508del-CFTR; biomarkers; cystic fibrosis (CF); disease phenotypes; infection; inflammation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Secuencia de Aminoácidos / Eliminación de Secuencia / Linfocitos T Colaboradores-Inductores / Mediadores de Inflamación / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Hermanos / Homocigoto Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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