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Western-style diet impedes colonization and clearance of Citrobacter rodentium.
An, Junqing; Zhao, Xu; Wang, Yanling; Noriega, Juan; Gewirtz, Andrew T; Zou, Jun.
Afiliación
  • An J; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
  • Zhao X; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
  • Wang Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Noriega J; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
  • Gewirtz AT; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
  • Zou J; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
PLoS Pathog ; 17(4): e1009497, 2021 04.
Article en En | MEDLINE | ID: mdl-33819308
Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to Citrobacter rodentium. We observed that, relative to mice consuming standard rodent grain-based chow (GBC), feeding WSD starkly altered the dynamics of Citrobacter infection, reducing initial colonization and inflammation but frequently resulting in persistent infection that associated with low-grade inflammation and insulin resistance. WSD's reduction in initial Citrobacter virulence appeared to reflect that colons of GBC-fed mice contain microbiota metabolites, including short-chain fatty acids, especially acetate, that drive Citrobacter growth and virulence. Citrobacter persistence in WSD-fed mice reflected inability of resident microbiota to out-compete it from the gut lumen, likely reflecting the profound impacts of WSD on microbiota composition. These studies demonstrate potential of altering microbiota and their metabolites by diet to impact the course and consequence of infection following exposure to a gut pathogen.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Colitis / Citrobacter rodentium / Infecciones por Enterobacteriaceae / Dieta Occidental / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: PLoS Pathog Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Colitis / Citrobacter rodentium / Infecciones por Enterobacteriaceae / Dieta Occidental / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: PLoS Pathog Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos