Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice.

McGonigal, Rhona; Barrie, Jennifer A; Yao, Denggao; Black, Lauren E; McLaughlin, Mark; Willison, Hugh J

McGonigal, Rhona; Barrie, Jennifer A; Yao, Denggao; Black, Lauren E; McLaughlin, Mark; Willison, Hugh J.

Afiliación

McGonigal R; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.
Barrie JA; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.
Yao D; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.
Black LE; School of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.
McLaughlin M; School of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.
Willison HJ; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.

J Neurochem ; 158(2): 217-232, 2021 07.

Article en En | MEDLINE | ID: mdl-33864399

Asunto(s)

Gangliósido G(M3)/metabolismo; Gangliósidos/metabolismo; Genes Letales/genética; Neuronas/metabolismo; Animales; Axones/patología; Trastornos Heredodegenerativos del Sistema Nervioso/genética; Trastornos Heredodegenerativos del Sistema Nervioso/patología; Inflamación/metabolismo; Microdominios de Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; N-Acetilgalactosaminiltransferasas/genética; Fenotipo; Nódulos de Ranvier/patología; Sialiltransferasas/genética; Análisis de Supervivencia; Polipéptido N-Acetilgalactosaminiltransferasa

Palabras clave

GM3; a-series gangliosides; nervous system integrity; transgenic mice

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gangliósido G(M3) / Gangliósidos / Genes Letales / Neuronas Límite: Animals Idioma: En Revista: J Neurochem Año: 2021 Tipo del documento: Article

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