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Stiffness-Dependent Intracellular Location of Cylindrical Polymer Brushes.
Niederberger, Antoine; Pelras, Théophile; Manni, Livia Salvati; FitzGerald, Paul A; Warr, Gregory G; Müllner, Markus.
Afiliación
  • Niederberger A; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Pelras T; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Manni LS; The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Sydney, NSW, 2006, Australia.
  • FitzGerald PA; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Warr GG; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Müllner M; Sydney Analytical, The University of Sydney, Sydney, NSW, 2006, Australia.
Macromol Rapid Commun ; 42(13): e2100138, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33871109
ABSTRACT
Cylindrical polymer brushes (CPBs) are macromolecules with nanoparticle proportions. Their modular synthesis enables tailoring of their chemical composition as well as the dialing-up of overall dimensions and physicochemical properties. In this study, two rod-like poly[(ethylene glycol) methyl ether methacrylate] (PEGMA)-based CPBs with varying stiffness but otherwise comparable features and functionality, are synthesized. Differences in particle stiffness are assessed using small angle neutron scattering (SANS). It is observed that the fate of the two CPBs within cells is distinctly different. Stiffer CPBs seem to gravitate toward the mitochondria, whereas CPBs with reduced stiffness are present in different intracellular vesicles.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polímeros / Nanopartículas Idioma: En Revista: Macromol Rapid Commun Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polímeros / Nanopartículas Idioma: En Revista: Macromol Rapid Commun Año: 2021 Tipo del documento: Article País de afiliación: Australia