Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study.
Psychol Med
; 53(1): 217-226, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-33949298
ABSTRACT
BACKGROUND:
In this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psychiatric hospitals in Denmark.METHODS:
Data were drawn from the iPSYCH2012 case-cohort sample, a population-based sample of individuals born in Denmark between 1981 and 2005. The sample included 18 532 individuals who were diagnosed with depression by a psychiatrist by age 31 years, and a comparison group of 20 184 individuals. Information on SLEs was obtained from nationwide registers and operationalized as a time-varying count variable. Hazard ratios and cumulative incidence rates were estimated using Cox regressions.RESULTS:
Risk for depression increased by 35% with each standard deviation increase in polygenic liability (p < 0.0001), and 36% (p < 0.0001) with each additional SLE. There was a small interaction between polygenic liability and SLEs (ß = -0.04, p = 0.0009). The probability of being diagnosed with depression in a hospital-based setting between ages 15 and 31 years ranged from 1.5% among males in the lowest quartile of polygenic liability with 0 events by age 15, to 18.8% among females in the highest quartile of polygenic liability with 4+ events by age 15.CONCLUSIONS:
These findings suggest that although there is minimal interaction between polygenic liability and SLEs as risk factors for hospital-treated depression, combining information on these two important risk factors could potentially be useful for identifying high-risk individuals.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Depresión
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Acontecimientos que Cambian la Vida
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Psychol Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Dinamarca