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Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study.
Lee, Chung-Han; Shah, Amishi Yogesh; Rasco, Drew; Rao, Arpit; Taylor, Matthew H; Di Simone, Christopher; Hsieh, James J; Pinto, Alvaro; Shaffer, David R; Girones Sarrio, Regina; Cohn, Allen Lee; Vogelzang, Nicholas J; Bilen, Mehmet Asim; Gunnestad Ribe, Sara; Goksel, Musaberk; Tennøe, Øyvind Krohn; Richards, Donald; Sweis, Randy F; Courtright, Jay; Heinrich, Daniel; Jain, Sharad; Wu, Jane; Schmidt, Emmett V; Perini, Rodolfo F; Kubiak, Peter; Okpara, Chinyere E; Smith, Alan D; Motzer, Robert J.
Afiliación
  • Lee CH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: leec4@mskcc.org.
  • Shah AY; Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
  • Rasco D; Department of Clinical Research, South Texas Accelerated Research Therapeutics, San Antonio, TX, USA.
  • Rao A; Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Taylor MH; Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR, USA.
  • Di Simone C; Medical Oncology/Hematology, Arizona Oncology Associates, Tucson, AZ, USA.
  • Hsieh JJ; Department of Medicine, Oncology Division, Washington University School of Medicine, St Louis, MO, USA.
  • Pinto A; Servicio de Oncología, Hospital Universitario La Paz, Madrid, Spain.
  • Shaffer DR; Medical Oncology, US Oncology Research, New York Oncology Hematology, Albany, NY, USA.
  • Girones Sarrio R; Medical Oncology Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Cohn AL; Medical Oncology, US Oncology Research, Rocky Mountain Cancer Center, Denver, CO, USA.
  • Vogelzang NJ; Department of Medical Oncology, US Oncology Research, US Oncology Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA.
  • Bilen MA; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
  • Gunnestad Ribe S; Medical Oncology, Sorlandet Hospital Kristiansand, Kristiansand, Norway.
  • Goksel M; Medical Oncology, Alaska Clinical Research Center, Anchorage, AK, USA.
  • Tennøe ØK; Sykehuset Østfold, Sarpsborg, Norway.
  • Richards D; Department of Oncology, US Oncology Research, Texas Oncology-Tyler, Tyler, TX, USA.
  • Sweis RF; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Courtright J; Department of Oncology, US Oncology Research, Texas Oncology, Dallas, TX, USA.
  • Heinrich D; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.
  • Jain S; Department of Oncology, US Oncology Research, Texas Oncology-Denton, Denton, TX, USA.
  • Wu J; Biostatistics, Eisai, Woodcliff Lake, NJ, USA.
  • Schmidt EV; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Perini RF; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Kubiak P; Clinical Research, Eisai, Woodcliff Lake, NJ, USA.
  • Okpara CE; Clinical Research, Eisai, Hatfield, UK.
  • Smith AD; Clinical Research, Eisai, Hatfield, UK.
  • Motzer RJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lancet Oncol ; 22(7): 946-958, 2021 07.
Article en En | MEDLINE | ID: mdl-34143969
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Fenilurea / Quinolinas / Carcinoma de Células Renales / Protocolos de Quimioterapia Combinada Antineoplásica / Inhibidores de Proteínas Quinasas / Anticuerpos Monoclonales Humanizados / Antineoplásicos Inmunológicos / Inhibidores de Puntos de Control Inmunológico / Neoplasias Renales Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Fenilurea / Quinolinas / Carcinoma de Células Renales / Protocolos de Quimioterapia Combinada Antineoplásica / Inhibidores de Proteínas Quinasas / Anticuerpos Monoclonales Humanizados / Antineoplásicos Inmunológicos / Inhibidores de Puntos de Control Inmunológico / Neoplasias Renales Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article