The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.
Annu Rev Biochem
; 90: 193-219, 2021 06 20.
Article
en En
| MEDLINE
| ID: mdl-34153211
In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by regulatory elements called enhancers, which are recognized by specific DNA-binding transcription factors that recruit cofactors and convey, following chromatin remodeling, the activating cues to the preinitiation complex. This review summarizes nearly five decades of work on transcription initiation by describing the sequential recruitment of diverse molecular players including the GTFs, the Mediator complex, and DNA repair factors that support RNAPII to enable RNA synthesis. The elucidation of the transcription initiation mechanism has greatly benefited from the study of altered transcription components associated with human diseases that could be considered transcription syndromes.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN Polimerasa II
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Secuencias Reguladoras de Ácidos Nucleicos
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Factor de Transcripción TFIID
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Factor de Transcripción TFIIH
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Iniciación de la Transcripción Genética
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2021
Tipo del documento:
Article