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Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt, Birte; Mastrobuoni, Guido; Wuenschel, Jasmin; Astrahantseff, Kathy; Eggert, Angelika; Kempa, Stefan; Deubzer, Hedwig E.
Afiliación
  • Arlt B; Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Mastrobuoni G; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
  • Wuenschel J; Berlin Institute of Health (BIH), Berlin, Germany.
  • Astrahantseff K; Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Eggert A; Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Kempa S; Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Deubzer HE; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
J Enzyme Inhib Med Chem ; 36(1): 1282-1289, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34192988
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperazinas / Piridinas / Tioamidas / Inhibidores Enzimáticos / Fosfoglicerato-Deshidrogenasa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperazinas / Piridinas / Tioamidas / Inhibidores Enzimáticos / Fosfoglicerato-Deshidrogenasa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Alemania