Chronic low-grade inflammation in heart failure with preserved ejection fraction.
Aging Cell
; 20(9): e13453, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34382743
ABSTRACT
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form of HF with a dramatic increase in risk with age. Low-grade inflammation, as occurs with aging (termed "inflammaging"), is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated HFpEF disease severity and better outcomes. From this perspective, inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression. However, the causal link between the inflammasome-immune signaling axis on the age-dependent progression of HFpEF remains conjectural. In this review, we summarize the current understanding of the role of inflammatory pathways in age-dependent cardiac function decline. We will also evaluate recent advances and evidence regarding the inflammatory pathway in the pathophysiology of HFpEF, with special attention to inflammasome signaling.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Volumen Sistólico
/
Insuficiencia Cardíaca
/
Inflamación
Límite:
Humans
Idioma:
En
Revista:
Aging Cell
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos