Fast Progression in Amyotrophic Lateral Sclerosis Is Associated With Greater TDP-43 Burden in Spinal Cord.

Cathcart, Sahara J; Appel, Stanley H; Peterson, Leif E; Greene, Ericka P; Powell, Suzanne Z; Arumanayagam, Anithachristy S; Rivera, Andreana L; Cykowski, Matthew D

Cathcart, Sahara J; Appel, Stanley H; Peterson, Leif E; Greene, Ericka P; Powell, Suzanne Z; Arumanayagam, Anithachristy S; Rivera, Andreana L; Cykowski, Matthew D.

Afiliación

Cathcart SJ; From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Appel SH; University of Nebraska Medical Center, Omaha, Nebraska, USA.
Peterson LE; Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas, USA.
Greene EP; Institute of Academic Medicine at the Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.
Powell SZ; Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas, USA.
Arumanayagam AS; NXG Logic, LLC, Houston, Texas, USA.
Rivera AL; Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas, USA.
Cykowski MD; Institute of Academic Medicine at the Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.

J Neuropathol Exp Neurol ; 80(8): 754-763, 2021 09 10.

Article en En | MEDLINE | ID: mdl-34383907

Asunto(s)

Esclerosis Amiotrófica Lateral/metabolismo; Proteínas de Unión al ADN/metabolismo; Médula Espinal/metabolismo; Adulto; Anciano; Esclerosis Amiotrófica Lateral/patología; Proteína C9orf72/metabolismo; Progresión de la Enfermedad; Femenino; Humanos; Masculino; Persona de Mediana Edad; Corteza Motora/metabolismo; Corteza Motora/patología; Médula Espinal/patología

Palabras clave

Amyotrophic lateral sclerosis; Lower motor neuron; Motor cortex; Progression rate; Spinal cord; TAR DNA-binding protein 43 kDa (TDP-43); Upper motor neuron

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Médula Espinal / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuropathol Exp Neurol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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