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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors.
Chamakuri, Srinivas; Lu, Shuo; Ucisik, Melek Nihan; Bohren, Kurt M; Chen, Ying-Chu; Du, Huang-Chi; Faver, John C; Jimmidi, Ravikumar; Li, Feng; Li, Jian-Yuan; Nyshadham, Pranavanand; Palmer, Stephen S; Pollet, Jeroen; Qin, Xuan; Ronca, Shannon E; Sankaran, Banumathi; Sharma, Kiran L; Tan, Zhi; Versteeg, Leroy; Yu, Zhifeng; Matzuk, Martin M; Palzkill, Timothy; Young, Damian W.
Afiliación
  • Chamakuri S; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Lu S; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030.
  • Ucisik MN; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Bohren KM; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Chen YC; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Du HC; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Faver JC; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Jimmidi R; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Li F; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Li JY; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030.
  • Nyshadham P; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Palmer SS; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Pollet J; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Qin X; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030.
  • Ronca SE; Center for Vaccine Development, Texas Children's Hospital, Houston, TX 77030.
  • Sankaran B; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Sharma KL; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030.
  • Tan Z; Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
  • Versteeg L; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Yu Z; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Matzuk MM; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030.
  • Palzkill T; Center for Vaccine Development, Texas Children's Hospital, Houston, TX 77030.
  • Young DW; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Proc Natl Acad Sci U S A ; 118(36)2021 09 07.
Article en En | MEDLINE | ID: mdl-34426525
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Descubrimiento de Drogas / Proteasas 3C de Coronavirus / SARS-CoV-2 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Descubrimiento de Drogas / Proteasas 3C de Coronavirus / SARS-CoV-2 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article