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Indole Alkaloids from a Soil-Derived Clonostachys rosea.
Jiang, Chun-Xiao; Yu, Bo; Miao, Ya-Mei; Ren, Hao; Xu, Qianhe; Zhao, Chun; Tian, Li-Li; Yu, Zhen-Qing; Zhou, Pan-Pan; Wang, Xiaolei; Fang, Jianguo; Zhang, Jiwen; Zhang, Jin Z; Wu, Quan-Xiang.
Afiliación
  • Jiang CX; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Yu B; School of Advanced Study, Taizhou University, Taizhou 318000, People's Republic of China.
  • Miao YM; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Ren H; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Xu Q; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhao C; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Tian LL; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Yu ZQ; Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
  • Zhou PP; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Wang X; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Fang J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhang J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhang JZ; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Wu QX; Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
J Nat Prod ; 84(9): 2468-2474, 2021 09 24.
Article en En | MEDLINE | ID: mdl-34427432
ABSTRACT
Clonorosins A (1) and B (2), two novel indole alkaloids featuring unprecedented 6/5/6/6/5 and 6/5/5 cores, together with seven known indole-linked 2,5-diketopiperazine alkaloids (3-9), were isolated from the soil-derived fungus Clonostachys rosea YRS-06. The new structures were proposed through HR-MS, NMR, and ECD spectroscopic data. They were established by comparing the calculated NMR, ECD, and specific rotation data with the experimental. To assist in determining the absolute configuration of the chiral carbon in the side chain of 2,5-diketopiperazine derivatives, flexible analogues 3i-3iv were synthesized and analyzed. 1 was active against Fusarium oxysporum with an MIC value of 50 µg/mL. 7 and 8 showed excellent activity against human HeLa and HepG2 cells with IC50 values of 0.12-0.60 µM.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alcaloides Indólicos / Hypocreales / Antibacterianos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alcaloides Indólicos / Hypocreales / Antibacterianos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article