hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Biology (Basel)
; 10(8)2021 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-34439945
ABSTRACT
The hnRNP A/B family of proteins is canonically central to cellular RNA metabolism, but due to their highly conserved nature, the functional differences between hnRNP A1, A2/B1, A0, and A3 are often overlooked. In this review, we explore and identify the shared and disparate homeostatic and disease-related functions of the hnRNP A/B family proteins, highlighting areas where the proteins have not been clearly differentiated. Herein, we provide a comprehensive assembly of the literature on these proteins. We find that there are critical gaps in our grasp of A/B proteins' alternative splice isoforms, structures, regulation, and tissue and cell-type-specific functions, and propose that future mechanistic research integrating multiple A/B proteins will significantly improve our understanding of how this essential protein family contributes to cell homeostasis and disease.
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Banco de datos:
MEDLINE
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En
Revista:
Biology (Basel)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá