All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials.
Adv Sci (Weinh)
; 8(21): e2100627, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34486241
ABSTRACT
Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio-temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing its development from broad scale application. Therefore, translating these technologies into tools for medical or pharmacological applications remains a challenge. Here, an all-optical nongenetic method for the modulation of electrogenic cells is introduced. It is demonstrated that plasmonic metamaterials can be used to elicit action potentials by converting near infrared laser pulses into stimulatory currents. The suggested approach allows for the stimulation of cardiomyocytes and neurons directly on commercial complementary metal-oxide semiconductor microelectrode arrays coupled with ultrafast pulsed laser, providing both stimulation and network-level recordings on the same device.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
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Miocitos Cardíacos
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Nanoestructuras
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Rayos Infrarrojos
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Neuronas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Adv Sci (Weinh)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia