Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice.

Hawkins, Nicole A; Jurado, Manuel; Thaxton, Tyler T; Duarte, Samantha E; Barse, Levi; Tatsukawa, Tetsuya; Yamakawa, Kazuhiro; Nishi, Toshiya; Kondo, Shinichi; Miyamoto, Maki; Abrahams, Brett S; During, Matthew J; Kearney, Jennifer A

Hawkins, Nicole A; Jurado, Manuel; Thaxton, Tyler T; Duarte, Samantha E; Barse, Levi; Tatsukawa, Tetsuya; Yamakawa, Kazuhiro; Nishi, Toshiya; Kondo, Shinichi; Miyamoto, Maki; Abrahams, Brett S; During, Matthew J; Kearney, Jennifer A.

Afiliación

Hawkins NA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jurado M; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thaxton TT; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Duarte SE; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Barse L; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Tatsukawa T; Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako, Japan.
Yamakawa K; Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako, Japan.
Nishi T; Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Ltd, Fujisawa, Japan.
Kondo S; Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Ltd, Fujisawa, Japan.
Miyamoto M; Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Ltd, Fujisawa, Japan.
Abrahams BS; Ovid Therapeutics, New York, New York, USA.
During MJ; Ovid Therapeutics, New York, New York, USA.
Kearney JA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Epilepsia ; 62(11): 2845-2857, 2021 11.

Article en En | MEDLINE | ID: mdl-34510432

Asunto(s)

Epilepsias Mioclónicas; Epilepsia; Piperidinas; Piridinas; Convulsiones Febriles; Muerte Súbita e Inesperada en la Epilepsia; Animales; Colesterol 24-Hidroxilasa/antagonistas & inhibidores; Epilepsias Mioclónicas/complicaciones; Epilepsias Mioclónicas/tratamiento farmacológico; Epilepsias Mioclónicas/genética; Epilepsia/genética; Síndromes Epilépticos; Ratones; Mortalidad Prematura; Mutación; Canal de Sodio Activado por Voltaje NAV1.1/genética; Piperidinas/farmacología; Piridinas/farmacología; Convulsiones/etiología; Convulsiones/genética; Convulsiones Febriles/tratamiento farmacológico; Muerte Súbita e Inesperada en la Epilepsia/etiología

Palabras clave

CYP46A1; Nav1.1 voltage-gated sodium channel; anticonvulsants; cholesterol 24-hydroxylase; epilepsy

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Epilepsias Mioclónicas / Convulsiones Febriles / Epilepsia / Muerte Súbita e Inesperada en la Epilepsia Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Epilepsia Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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